Association of Inherited Genotype and Severity of Clinical Presentation in Subjects with Verified Pas III Disorder.

ABSTRACT:

Background

Polyglandular autoimmune syndrome type III (PAS III) is combination two most common autoimmune disease: Diabetes mellytus type 1 (DM1) and autoimmune thyroid disease (AITD).

Objectives

The aims of the study were a) to define conection between polymorphism of CTLA-4 gene, rs 231775 with PAS III; b) to establish the conection of inherited genotype with severity of clinical features; and c) to estimate the rate of risk for severe clinical presentation among subgroups in study population.

Methods

This research included 50 subjects with diagnosed PAS III syndrome, wich are on treatment in clinic for Nuclear medicine and andocrinology KCUS. As methods of research has used: hystory of disesase AND clinical examination. As material is used blood sample. From blood

SUBMITTER: Beslic VK 

PROVIDER: S-EPMC9478524 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature