Ultrasomics prediction for cytokeratin 19 expression in hepatocellular carcinoma: A multicenter study.

ABSTRACT:

Objective

The purpose of this study was to investigate the preoperative prediction of Cytokeratin (CK) 19 expression in patients with hepatocellular carcinoma (HCC) by machine learning-based ultrasomics.

Methods

We retrospectively analyzed 214 patients with pathologically confirmed HCC who received CK19 immunohistochemical staining. Through random stratified sampling (ratio, 8:2), patients from institutions I and II were divided into training dataset (n = 143) and test dataset (n = 36), and patients from institution III served as external validation dataset (n = 35). All gray-scale ultrasound images were preprocessed, and then the regions of interest were then manually segmented by two sonographers. A total of 1409 ultrasomics features were extracted from the original and de

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9478580 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature