Inferring the initiation and development of myeloproliferative neoplasms.

ABSTRACT: The developmental history of blood cancer begins with mutation acquisition and the resulting malignant clone expansion. The two most prevalent driver mutations found in myeloproliferative neoplasms-JAK2^V617F and CALR^m-occur in hematopoietic stem cells, which are highly complex to observe in vivo. To circumvent this difficulty, we propose a method relying on mathematical modeling and statistical inference to determine disease initiation and dynamics. Our findings suggest that CALR^m mutations tend to occur later in life than JAK2^V617F. Our results confirm the higher proliferative advantage of the CALR^m malignant clone compared to JAK2^V617F. Furthermore, we illustrate how mathematical m

SUBMITTER: Hermange G 

PROVIDER: S-EPMC9478641 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature