The pattern of expression and prognostic value of key regulators for m⁷G RNA methylation in hepatocellular carcinoma.

ABSTRACT: N7-methylguanosine (m⁷G) modification on internal RNA positions plays a vital role in several biological processes. Recent research shows m⁷G modification is associated with multiple cancers. However, in hepatocellular carcinoma (HCC), its implications remain to be determined. In this place, we need to interrogate the mRNA patterns for 29 key regulators of m⁷G RNA modification and assess their prognostic value in HCC. Initial, the details from The Cancer Genome Atlas (TCGA) database concerning transcribed gene data and clinical information of HCC patients were inspected systematically. Second, according to the mRNA profiles of 29 m⁷G RNA methylation regulators, two clusters (named 1 and 2, respectively) were identified by consensus clustering. Fu

SUBMITTER: Chen J 

PROVIDER: S-EPMC9478798 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature