Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial.

ABSTRACT:

Importance

The efficacy of laparoscopic vs open surgery for patients with low rectal cancer has not been established.

Objective

To compare the short-term efficacy of laparoscopic surgery vs open surgery for treatment of low rectal cancer.

Design, setting, and participants

This multicenter, noninferiority randomized clinical trial was conducted in 22 tertiary hospitals across China. Patients scheduled for curative-intent resection of low rectal cancer were randomized at a 2:1 ratio to undergo laparoscopic or open surgery. Between November 2013 and June 2018, 1070 patients were randomized to laparoscopic (n = 712) or open (n = 358) surgery. The planned follow-up was 5 years. Data analysis was performed from April 2021 to March 2022.

Interventions

Eligible patient

SUBMITTER: Jiang WZ 

PROVIDER: S-EPMC9478880 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature