Hydrodynamic Cavitation on a Chip: A Tool to Detect Circulating Tumor Cells.

ABSTRACT: Circulating tumor cells (CTCs) are essential biomarkers for cancer diagnosis. Although various devices have been designed to detect, enumerate, and isolate CTCs from blood, some of these devices could have some drawbacks, such as the requirement of labeling, long process time, and high cost. Here, we present a microfluidic device based on the concept of "hydrodynamic cavitation-on-chip (HCOC)", which can detect CTCs in the order of minutes. The working principle relies on the difference of the required inlet pressure for cavitation inception of working fluids when they pass through the microfluidic device. The interface among the solid/floating particles, liquid, and vapor phases plays an important role in the strength of the fluid to withstand the rupture and cavitation formation. To this

SUBMITTER: Namli I 

PROVIDER: S-EPMC9478945 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature