Systematic pan‑cancer analysis identifies CDC45 as having an oncogenic role in human cancers.

ABSTRACT: Cell division cycle 45 (CDC45) is an essential protein required for the initiation of DNA replication. In the present study, the role of CDC45 across 33 cancers was systematically investigated. It was observed that the expression of CDC45 was significantly upregulated in most cancers, exhibiting a marked negative correlation with the overall survival. Next, there was no significant difference in prognosis between the genomically altered and unaltered groups with respect to clinical outcomes. A decreased level of CDC45 at the DNA promoter region was also identified in several cancers. Furthermore, CDC45 expression was associated with the levels of tumor‑infiltrating immune cells in some specific cancer types. In addition, CDC45 was associated with m⁶A methylation, and CDC45 expre

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9478988 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature