Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.

ABSTRACT: Osteoarthritis (OA) is a progressive degenerative joint disease characterized by the destruction of the articular cartilage, meniscus and the like. Autophagy and cellular energy metabolism are the mechanisms by which cells maintain homeostasis. However, little is known about the effects of autophagy and cellular energy metabolism on meniscus degeneration, and the pathogenesis of posttraumatic osteoarthritis (PTOA) after the meniscal injury is rarely reported. Therefore, this study aimed to investigate the relationship between changes in autophagy and cellular energy metabolism in the meniscus following anterior cruciate ligament transection (ACLT) and PTOA induced by subsequent articular cartilage injury. In this study, we use a combination of cell experiments in vitro and animal ex

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9479128 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature