Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter?

ABSTRACT: Lung and colorectal cancers are among the leading causes of death from cancer worldwide. Although topotecan (TPT), a topoisomerase1 inhibitor, is a first- and second-line drug for lung and colon cancers, the development of drug resistance and toxicity still remain as a major obstacle to chemotherapeutic success. Accumulating evidence indicates increased efficacy and reduced toxicity of chemotherapeutic agents upon combining them with natural products. We aimed to investigate the possible interaction of safranal (SAF), a natural compound obtained from Crocus sativus stigma, with TPT when used in different sequences in colon and lung cancer cell lines. The growth inhibitory effect of the proposed combination given in different sequences was assessed using the colony formation assay. T

SUBMITTER: Lozon L 

PROVIDER: S-EPMC9479137 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature