Specific classification and new therapeutic targets for neuroendocrine prostate cancer: A patient-based, diagnostic study.

ABSTRACT: Objective: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer (PC) that may arise de novo or in patients previously treated with hormonal therapies for prostate adenocarcinoma as a mechanism of resistance. In our investigation, there appeared to be a strong correlation between neuroendocrine differentiation prostate cancer (NEDPC) and NEPC. The objectives of this study included exploring whether NEDPC is an intermediate stage in the progression of high-risk prostate cancer (HRPC) to NEPC and identifying risk factors and new targets associated with survival in the treatment of NEPC. Methods: The selected prostate cancer patients were progressed to high-risk and characterized by neuroendocrine. We collected the clinical data and characteris

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9479159 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature