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New Approaches to Glioblastoma.


ABSTRACT: Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.

SUBMITTER: Khasraw M 

PROVIDER: S-EPMC9479165 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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New Approaches to Glioblastoma.

Khasraw Mustafa M   Fujita Yoko Y   Lee-Chang Catalina C   Balyasnikova Irina V IV   Najem Hinda H   Heimberger Amy B AB  

Annual review of medicine 20211019


Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment fo  ...[more]

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