Association of circulating branched-chain amino acids with risk of moyamoya disease.

ABSTRACT:

Objective

Branched-Chain Amino Acids (BCAAs) has been identified as a risk factor for circulatory disease. Nevertheless, the effects and mechanisms of BCAAs on the risk of moyamoya disease (MMD) remain unrecognized. Hence, we aimed to elucidate the association between circulating BCAAs and the risk of MMD and clinical subtypes.

Methods

We conducted a case-control study of 360 adult MMD patients and 89 matched healthy controls consecutively recruited between September 2020 and December 2021. Serum level of BCAAs was quantified by liquid chromatography-mass spectrometry. The associations between BCAAs and risk of MMD were evaluated.

Results

Increased level of serum BCAAs was observed in MMD patients (P < 0.001). After adjusting for traditional confounders, the el

SUBMITTER: Zeng C 

PROVIDER: S-EPMC9479188 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature