Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells.

ABSTRACT:

Background

Transcription factors (TFs) play central roles in maintaining "stemness" of embryonic stem (ES) cells and their differentiation into several hundreds of adult cell types. The regulatory competence of TFs is routinely assessed by detecting target genes to which they bind. However, these data do not indicate which target genes are activated, repressed, or not affected by the change of TF abundance. There is a lack of large-scale studies that compare the genome binding of TFs with the expression change of target genes after manipulation of each TF.

Results

In this paper we associated human TFs with their target genes by two criteria: binding to genes, evaluated from published ChIP-seq data (n = 1868); and change of target gene expression shortly after induction of ea

SUBMITTER: Sharov AA 

PROVIDER: S-EPMC9479252 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature