Twenty-year trends in racial and ethnic enrollment in large diabetes randomized controlled trials.

ABSTRACT:

Background

Lack of representativeness in Black, Indigenous, and People of Colour (BIPOC) enrollment could compromise the generalizability of study results and health equity. This study aimed to examine trends in BIPOC groups enrollment in diabetes randomized controlled trials (RCTs) and to explore the association between trial factors and high-enrollment of BIPOC groups.

Methods

We systematically searched the literature on large diabetes RCTs with a sample size of ≥ 400 participants published between 2000 and 2020. We assessed temporal trends in enrollment of racial and ethnic groups in the included trials. Logistic and linear regression analyses were used to explore the relationship between trial factors and the high-enrollment defined by median enrollment rate.

Results<

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9479279 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature