Repositioning of drugs for Parkinson's disease and pharmaceutical nanotechnology tools for their optimization.

ABSTRACT: Parkinson's disease (PD) significantly affects patients' quality of life and represents a high economic burden for health systems. Given the lack of safe and effective treatments for PD, drug repositioning seeks to offer new medication alternatives, reducing research time and costs compared to the traditional drug development strategy. This review aimed to collect evidence of drugs proposed as candidates to be reused in PD and identify those with the potential to be reformulated into nanocarriers to optimize future repositioning trials. We conducted a detailed search in PubMed, Web of Science, and Scopus from January 2015 at the end of 2021, with the descriptors "Parkinson's disease" and "drug repositioning" or "drug repurposing". We identified 28 drugs as potential candidates, and six of

SUBMITTER: Hernandez-Parra H 

PROVIDER: S-EPMC9479294 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature