Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study.

ABSTRACT:

Background

Oxidative stress is currently considered to be closely related to the occurrence of respiratory tumors, especially lung cancer. Many observational studies have shown that increased antioxidant intake can reduce the risk of lung cancer, but the results are still controversial. Therefore, we performed a two-sample Mendelian randomized (MR) analysis to clarify the causal relationship between antioxidant vitamins and lung cancer.

Methods

To assess the causal effect of dietary antioxidant vitamin intake on lung cancer, we conducted a two-sample MR analysis and we extracted single-nucleotide polymorphisms (SNPs) that are associated with antioxidants from genome-wide association studies (GWASs) of the UK biobank. We gathered summary data for lung cancer from the Internat

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9479338 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature