SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia.

ABSTRACT:

Background

Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected in the underlying SARS-CoV-2 antibody responses.

Methods

We measured IgM, IgA, and IgG levels against SARS-CoV-2 spike and nucleocapsid antigens in 1076 adults of a cohort study in Catalonia between June and November 2020 and a second time between May and July 2021. Questionnaire data and electronic health records on vaccination and COVID-19 testing were available in both periods. Data on several lifestyle, health-related, and sociodemographic characteristics were also available.

Results

Antibody seroreversion occurred in 35.8% of the 64 participants non-vaccinated and infected almost a year ago and was related to asymptomatic infecti

SUBMITTER: Karachaliou M 

PROVIDER: S-EPMC9479347 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature