Distinct sex-specific DNA methylation differences in Alzheimer's disease.

ABSTRACT:

Background

Sex is increasingly recognized as a significant factor contributing to the biological and clinical heterogeneity in AD. There is also growing evidence for the prominent role of DNA methylation (DNAm) in Alzheimer's disease (AD).

Methods

We studied sex-specific DNA methylation differences in the blood samples of AD subjects compared to cognitively normal subjects, by performing sex-specific meta-analyses of two large blood-based epigenome-wide association studies (ADNI and AIBL), which included DNA methylation data for a total of 1284 whole blood samples (632 females and 652 males). Within each dataset, we used two complementary analytical strategies, a sex-stratified analysis that examined methylation to AD associations in male and female samples separately, and a

SUBMITTER: C Silva T 

PROVIDER: S-EPMC9479371 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature