Drinking water nitrate and risk of pregnancy loss: a nationwide cohort study.

ABSTRACT:

Background

Nitrate contamination is seen in drinking water worldwide. Nitrate may pass the placental barrier. Despite suggestive evidence of fetal harm, the potential association between nitrate exposure from drinking water and pregnancy loss remains to be studied. We aimed to investigate if nitrate in drinking water was associated with the risk of pregnancy loss.

Methods

We conducted a nationwide cohort study of 100,410 pregnancies (enrolled around gestational week 11) in the Danish National Birth Cohort (DNBC) during 1996-2002. Spontaneous pregnancy losses before gestational week 22 were ascertained from the Danish National Patient Registry and DNBC pregnancy interviews. Using the national drinking water quality-monitoring database Jupiter, we estimated the individual and

SUBMITTER: Ebdrup NH 

PROVIDER: S-EPMC9479399 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature