Association of cholinesterase activities and POD in older adult abdominal surgical patients.

ABSTRACT:

Background

Postoperative delirium (POD) is a frequent complication after surgery. Older adult patients undergoing abdominal surgery are at higher risk for developing POD. Studies on the association of cholinesterase activities and POD are rare, but leading hypotheses implicate that the cholinergic pathway might play an important role in neuroinflammation and development of POD. The objective of this study was to figure out if there is an association between the development of POD and acetyl- and butyrylcholinesterase (AChE and BuChE) activities in older adult patients undergoing abdominal surgery.

Methods

The investigation was performed with a subpopulation of BioCog study patients. The BioCog project ( http://www.biocog.eu ) is a prospective multicenter observational study

SUBMITTER: Bosancic Z 

PROVIDER: S-EPMC9479414 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature