PROTACs: The Future of Leukemia Therapeutics.
Ontology highlight
ABSTRACT:
SUBMITTER: Anwar Z
PROVIDER: S-EPMC9479449 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
PROTACs: The Future of Leukemia Therapeutics.
Anwar Zubair Z Ali Muhammad Shahzad MS Galvano Antonio A Perez Alessandro A La Mantia Maria M Bukhari Ihtisham I Swiatczak Bartlomiej B
Frontiers in cell and developmental biology 20220902
The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of ...[more]
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