Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels.

ABSTRACT: Blue light (BL) is becoming increasingly prevalent in artificial illumination, raising concerns about its potential health hazard to humans. In fact, there is evidence suggesting that acute BL exposure may lead to oxidative stress and death of retinal cells specialized for photoreception. On the other hand, recent studies in Drosophila melanogaster demonstrated that chronic BL exposure across lifespan leads to accelerated aging manifested in reduced lifespan and brain neurodegeneration even in flies with genetically ablated eyes, suggesting that BL can damage cells and tissues not specialized for light perception. At the physiological level, BL exposure impairs mitochondria function in flies, but the metabolic underpinnings of these effects have not been studied. Here, we investigat

SUBMITTER: Yang J 

PROVIDER: S-EPMC9479496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature