Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways.

ABSTRACT:

Purpose

Dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy (RION) after single-fraction stereotactic radiosurgery (SRS) or hypofractionated (2-5 fractions) radiosurgery (fSRS) were analyzed from pooled data that were extracted from published reports (PubMed indexed from 1990 to June 2015). This study was undertaken as part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy, investigating normal tissue complication probability (NTCP) after hypofractionated radiation.

Methods and materials

Eligible studies described dose delivered to optic nerve/chiasm and provided crude or actuarial toxicity risks, with visual endpoints (ie, loss of visual acuity, alterations in visual fields, and/or blindne

SUBMITTER: Milano MT 

PROVIDER: S-EPMC9479557 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature