Cord blood sphingolipids are associated with atopic dermatitis and wheeze in the first year of life.

ABSTRACT:

Background

Allergen-sensitized pregnant mice have increased plasma levels of the lipids β-glucosylceramides (βGlcCers) that are transplacentally transferred to the fetus, increased subsets of proinflammatory dendritic cells in the fetal liver and pup lung, and increased allergen-induced offspring lung inflammation.

Objective

Our aim was to determine whether these preclinical observations extend to a human association of βGlcCers with wheeze and allergic disease in the prospective Wisconsin Infant Study Cohort.

Methods

We measured 74 lipids in cord blood plasma by using mass spectrometry detection of sphingolipids, eicosanoids, and docosinoids, as well as an ELISA for 13-hydroxyoctadecadienoic acid. Lipid profiles were determined by unbiased Uniform Manifold Approximat

SUBMITTER: Hoji A 

PROVIDER: S-EPMC9479978 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature