Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice.

ABSTRACT:

Introduction

Increasing age is the number one risk factor for developing cognitive decline and neurodegenerative disease. Aged humans and mice exhibit numerous molecular changes that contribute to a decline in cognitive function and increased risk of developing age-associated diseases. Here, we characterize multiple age-associated changes in male C57BL/6J mice to understand the translational utility of mouse aging.

Methods

Male C57BL/6J mice from various ages between 2 and 24 months of age were used to assess behavioral, as well as, histological and molecular changes across three modalities: neuronal, microgliosis/neuroinflammation, and the neurovascular unit (NVU). Additionally, a cohort of 4- and 22-month-old mice was used to assess blood-brain barrier (BBB) breakdown. Mic

SUBMITTER: Britton R 

PROVIDER: S-EPMC9480918 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature