Two-layer analytical model for estimation of layer thickness and flow using Diffuse Correlation Spectroscopy.

ABSTRACT: Diffuse correlation spectroscopy (DCS) has been widely explored for its ability to measure cerebral blood flow (CBF), however, mostly under the assumption that the human head is homogenous. In addition to CBF, knowledge of extracerebral layers, such as skull thickness, can be informative and crucial for patient with brain complications such as traumatic brain injuries. To bridge the gap, this study explored the feasibility of simultaneously extracting skull thickness and flow in the cortex layer using DCS. We validated a two-layer analytical model that assumed the skull as top layer with a finite thickness and the brain cortex as bottom layer with semi-infinite geometry. The model fitted for thickness of the top layer and flow of the bottom layer, while assumed other parameters as constant

SUBMITTER: Wu J 

PROVIDER: S-EPMC9481000 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature