Longitudinal study of the immune response and memory following natural bovine respiratory syncytial virus infections in cattle of different age.

ABSTRACT: Human and bovine respiratory syncytial virus (HRSV and BRSV) are closely genetically related and cause respiratory disease in their respective host. Whereas HRSV vaccines are still under development, a multitude of BRSV vaccines are used to reduce clinical signs. To enable the design of vaccination protocols to entirely stop virus circulation, we aimed to investigate the duration, character and efficacy of the immune responses induced by natural infections. The systemic humoral immunity was monitored every two months during two years in 33 dairy cattle in different age cohorts following a natural BRSV outbreak, and again in selected individuals before and after a second outbreak, four years later. Local humoral and systemic cellular responses were also monitored, although less extensively.

SUBMITTER: Hagglund S 

PROVIDER: S-EPMC9481050 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature