The Risk of Type 2 Diabetes in Patients With Inflammatory Bowel Disease After Bowel Resections: A Nationwide Cohort Study.

ABSTRACT:

Background and aims

Patients with inflammatory bowel disease (IBD) are at increased risk of type 2 diabetes (T2D), but the underlying mechanisms remain elusive. We aimed to determine the impact of small and large bowel resections on the risk of developing T2D in patients with IBD.

Methods

We conducted a nationwide, prospective study of all IBD patients undergoing small bowel resection (Crohn's disease [CD]) and large bowel resection (CD and ulcerative colitis [UC]) in Denmark (1996-2018). Each patient was matched with up to 5 patients with IBD and no history of bowel resection. We used Cox proportional hazards regression models to estimate adjusted hazard ratios (aHRs) of T2D.

Results

We included 2469 patients with CD and small bowel resection, 1361 patients with CD a

SUBMITTER: Allin KH 

PROVIDER: S-EPMC9481066 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature