Altered composition of the oral microbiome in integrin beta 6-deficient mouse.

ABSTRACT: In periodontal disease (PD), bacterial biofilms suppress β6 integrin expression transforming growth factor-β1 signaling, resulting in gingival inflammation and bone loss. β6 integrin-null (Itgb6^-/- ) mice develop spontaneous PD. The aim of this study was to unravel potential differences in oral microbiome in wild-type (WT) and Itgb6^-/- FVB mice. Mouse oral microbiome was analyzed from 3- and 6-month-old WT and Itgb6^-/- . The periodontal inflammation and spontaneous bone loss were present in 3-month-old and advanced in 6-month-old Itgb6^-/- mice. The observed amplicon sequence variants (ASVs) of alpha diversity showed close similarity in 3-month-old and 6-month-old Itgb6^-/- mice. Chao1 and ACE methods r

SUBMITTER: Uehara O 

PROVIDER: S-EPMC9481083 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature