Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a leading cause of infectious disease mortality. Animal infection models have contributed substantially to our understanding of TB, yet their biological and non-biological limitations are a research bottleneck. There is a need for more ethically acceptable, economical, and reproducible TB infection models capable of mimicking key aspects of disease. Here, we demonstrate and present a basic description of how Galleria mellonella (the greater wax moth, Gm) larvae can be used as a low cost, rapid, and ethically more acceptable model for TB research. This is the first study to infect Gm with the fully virulent MTB H37Rv, the most widely used strain in research. Infection of Gm wit

SUBMITTER: Asai M 

PROVIDER: S-EPMC9481108 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature