Cluster analysis of lymphocyte subset from peripheral blood in newly diagnosed idiopathic aplastic anaemia patients.

ABSTRACT:

Introduction

Idiopathic aplastic anaemia (IAA) is a heterogeneous autoimmune disease characterised by pancytopenia and bone marrow failure. The objective of the study was to investigate the clusters of lymphocyte subset in newly diagnosed IAA patients and explore their correlation with clinical characteristics.

Methods

A total of 124 newly diagnosed IAA patients were enrolled. Lymphocyte subset was detected by flow cytometry. Cluster analysis was conducted to identify subgroups of patients based on lymphocyte subset.

Results

Cluster analysis classified patients into four distinctive subgroups: Cluster 1 (CD4⁺ T cells dominant), Cluster 2 (CD8⁺ T cells dominant), Cluster 3 (NK cells dominant) and Cluster 4 (B cells dominant). Patients in Clusters

SUBMITTER: Yu W 

PROVIDER: S-EPMC9481148 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature