Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.

ABSTRACT: The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate only glutamatergic excitatory neurons despite being exposed to signals with the potential to initiate the production of other neuronal types, suggesting that their competence is limited. Here, we tested the hypothesis that this limitation is due to their expression of transcription factor Pax6. We used bulk and single-cell RNAseq to show that conditional cortex-specific Pax6 deletion from the onset of cortical neurogenesis allowed some progenitors to generate abnormal lineages resembling those normally found outside the cortex. Analysis of selec

SUBMITTER: Manuel M 

PROVIDER: S-EPMC9481180 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature