Polygenic signals of sex differences in selection in humans from the UK Biobank.

ABSTRACT: Sex differences in the fitness effects of genetic variants can influence the rate of adaptation and the maintenance of genetic variation. For example, "sexually antagonistic" (SA) variants, which are beneficial for one sex and harmful for the other, can both constrain adaptation and increase genetic variability for fitness components such as survival, fertility, and disease susceptibility. However, detecting variants with sex-differential fitness effects is difficult, requiring genome sequences and fitness measurements from large numbers of individuals. Here, we develop new theory for studying sex-differential selection across a complete life cycle and test our models with genotypic and reproductive success data from approximately 250,000 UK Biobank individuals. We uncover polygenic signal

SUBMITTER: Ruzicka F 

PROVIDER: S-EPMC9481184 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature