Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials.

ABSTRACT:

Background

Low muscle in cancer is associated with an increase in treatment-related toxicities and is a predictor of cancer-related and all-cause mortality. The mechanisms of cancer-related muscle loss are multifactorial, including anorexia, hypogonadism, anaemia, inflammation, malnutrition, and aberrations in skeletal muscle protein turnover and metabolism.

Methods

In this narrative review, we summarise relevant literature to (i) review the factors influencing skeletal muscle mass regulation, (ii) provide an overview of how cancer/treatments negatively impact these, (iii) review factors beyond muscle signalling that can impact the ability to participate in and respond to an exercise intervention to counteract muscle loss in cancer, and (iv) provide perspectives on critical

SUBMITTER: Fairman CM 

PROVIDER: S-EPMC9481195 | biostudies-literature | 2022 Jan-Jun

REPOSITORIES: biostudies-literature