The role of metabolites under the influence of genes and lifestyles in bone density changes.

ABSTRACT:

Purpose

Osteoporosis is a complex bone disease influenced by numerous factors. Previous studies have found that some metabolites are related to bone mineral density (BMD). However, the associations between metabolites and BMD under the influence of genes and lifestyle have not been fully investigated.

Methods

We analyzed the effect of metabolites on BMD under the synergistic effect of genes and lifestyle, using the data of 797 participants aged 55-65 years from the Taizhou Imaging Study. The cumulative sum method was used to calculate the polygenic risk score of SNPs, and the healthful plant-based diet index was used to summarize food intake. The effect of metabolites on BMD changes under the influence of genes and lifestyle was analyzed through interaction analysis and medi

SUBMITTER: Lv X 

PROVIDER: S-EPMC9481263 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature