IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.

ABSTRACT:

Objective

In the development of many tumors, IPO5, as a member of the nuclear transporter family, exerts a significant function. Also, IPO5 is used as a therapeutic target for tumors based on some reports. By studying IPO5 expression in esophageal cancer tissues, the mechanism associated with IPO5 improving esophageal cancer development was explored in this study.

Methods

To gain differentially expressed genes, this study utilized mRNA microarray and TCGA database for comprehensive analysis of esophageal cancer tissues and normal esophageal cancer tissues, and then the differentially expressed gene IPO5 was screened by us. To assess esophageal cancer patients' prognosis, this study also applied the Kaplan-Meier analysis, and we also conducted the GSEA enrichment analysis to

SUBMITTER: Li M 

PROVIDER: S-EPMC9481360 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature