Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis.

ABSTRACT:

Background

Epigenetics, and especially DNA methylation, contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). This study aimed to investigate the role of DNA methylation in SALS using whole blood of SALS patients.

Methods

In total, 32 SALS patients and 32 healthy controls were enrolled in this study. DNA was isolated from whole blood collected from the participants. DNA methylation profiles were generated using Infinium MethylationEPIC BeadChip.

Results

We identified 34 significant differentially methylated positions (DMPs) in whole blood from SALS patients, compared with the healthy controls. Of these DMPs, five were hypermethylated and 29 were hypomethylated; they corresponded to 13 genes. For the DMPs, ATAD3B and BLK were hypermethylated

SUBMITTER: Cai Z 

PROVIDER: S-EPMC9481424 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature