An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis.

ABSTRACT:

Background

Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.

Methods

A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke.

Results

Multivariate regression analysi

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9481432 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature