A proof of concept for targeting the PrP^C - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer.

ABSTRACT: The cellular prion protein PrP^C partners with caveolin-1 (CAV1) in neurodegenerative diseases but whether this interplay occurs in cancer has never been investigated. By leveraging patient and cell line datasets, we uncover a molecular link between PrP^C and CAV1 across cancer. Using cell-based assays, we show that PrP^C regulates the expression of and interacts with CAV1. PrP^C additionally controls the expression of the amyloid precursor protein APP and of the Aβ generating enzyme BACE1, and regulates the levels of Aβ, whose accumulation is a central event in Alzheimer's disease. We further identify DKK1 and DKK3, involved in both Alzheimer's disease and cancer progression, as targets of the PrP^C-dependent axis. Finally, we establish th

SUBMITTER: Mouillet-Richard S 

PROVIDER: S-EPMC9481457 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature