The rs1001179 SNP and CpG methylation regulate catalase expression in chronic lymphocytic leukemia.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by an extremely variable clinical course. We have recently shown that high catalase (CAT) expression identifies patients with an aggressive clinical course. Elucidating mechanisms regulating CAT expression in CLL is preeminent to understand disease mechanisms and develop strategies for improving its clinical management. In this study, we investigated the role of the CAT promoter rs1001179 single nucleotide polymorphism (SNP) and of the CpG Island II methylation encompassing this SNP in the regulation of CAT expression in CLL. Leukemic cells harboring the rs1001179 SNP T allele exhibited a significantly higher CAT expression compared with cells bearing the CC genotype. CAT promoter harboring the T -but not C- allele wa

SUBMITTER: Galasso M 

PROVIDER: S-EPMC9481481 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature