Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice.

ABSTRACT:

Rationale

The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among adolescents, posing major medical and psychiatric risks. JWH-018 represents the reference compound of SCRA-containing products.

Objectives

This study was performed to evaluate the enduring consequences of adolescent voluntary consumption of JWH-018.

Methods

The reinforcing properties of JWH-018 were characterized in male CD1 adolescent mice by intravenous self-administration (IVSA). Afterwards, behavioral, neurochemical, and molecular evaluations were performed at adulthood.

Results

Adolescent mice acquired operant behavior (lever pressing, Fixed Ratio 1-3; 7.5 µg/kg/inf); this behavior was specifically directed at obtaining JWH-018 since it increased under Progressive Ratio s

SUBMITTER: Margiani G 

PROVIDER: S-EPMC9481487 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature