Modeling of the combined dynamics of leptospirosis transmission and seroconversion in herds.

ABSTRACT: Leptospirosis is a zoonotic disease-causing illness in both humans and animals resulting in related economic impacts due to production loss as well as prevention and control efforts. Several mathematical models have been proposed to study the dynamics of infection but none of them has so far taken into account the dynamics of seroconversion. In this study, we have developed a general framework, based on the kinetic model for animal leptospirosis, that combines both the antibody (exposure marker) and infection dynamics to simultaneously follows both seroconversion and infection status of leptospirosis in a herd population. It is a stochastic compartmental model (for transition rates) with time delay (for seroconversion) which describes the progression of infection by a SEIRS (susceptible, e

SUBMITTER: Chadsuthi S 

PROVIDER: S-EPMC9481562 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature