Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.

ABSTRACT: With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically understanding the genetics of the natural history of complex diseases. Genome-wide survival association analysis can identify genetic variants associated with ages of onset, disease progression and lifespan. We propose an efficient and accurate frailty model approach for genome-wide survival association analysis of censored time-to-event (TTE) phenotypes by accounting for both population structure and relatedness. Our method utilizes state-of-the-art optimization strategies to reduce the computational cost. The saddlepoint approximation is used to allow for analysis of heavily censored phenotypes (>90%) and low frequency variants (down to minor allele coun

SUBMITTER: Dey R 

PROVIDER: S-EPMC9481565 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature