The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation.

ABSTRACT: During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to joint cavities where hypertrophic differentiation and endochondral bone formation are prevented, and chondrocytes instead form articular cartilage. The mechanisms that prevent hypertrophic differentiation and endochondral bone formation of the articular cartilage have not been elucidated. To explore the role of the synovial microenvironment in chondrocyte differentiation, osteochondral allografts consisting of articular cartilage, epiphyseal bone, and growth plate cartilage from distal femoral epiphyses of inbred Lewis rats expressing enhanced green fluorescent protein from a ubiquitous promoter were transpla

SUBMITTER: Chau M 

PROVIDER: S-EPMC9481641 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature