A treatment-specific marginal structural Cox model for the effect of treatment discontinuation.

ABSTRACT: Patients taking a prescribed medication often discontinue their treatment; however, this may negatively impact their health outcomes. If doctors had statistical evidence that discontinuing some prescribed medication shortened, on average, the time to a clinical event (e.g., death), they could use that knowledge to encourage their patients to stay on the prescribed treatment. We describe a treatment-specific marginal structural Cox model for estimation of the causal effect of treatment discontinuation on a survival endpoint. The effect of treatment discontinuation is quantified by the hazard ratio of the event hazard rate had the population followed the regime "take treatment a until it is discontinued at some time ν ," versus the event hazard rate had the population never discontinued tr

SUBMITTER: Johnson D 

PROVIDER: S-EPMC9481666 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature