Neuroblast migration along cellular substrates in the developing porcine brain.

ABSTRACT: In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models. We reasoned that migratory streams of neuroblasts utilize cellular substrates, such as blood vessels, to guide their trek from the subventricular zone to distant cortical targets. Here, we evaluate the association between young interneuronal migratory streams and

SUBMITTER: Porter DDL 

PROVIDER: S-EPMC9481921 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature