ALS-linked loss of Cyclin-F function affects HSP90.

ABSTRACT: The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)^Cyclin-F which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the substrate adaptor function of Cyclin-F and whether altered SCF^Cyclin-F-mediated ubiquitination contributes to pathogenesis in <i>CCNF</i> mutation carriers. To address these questions, we set out to identify new SCF^Cyclin-F targets in neuronal and ALS pat

SUBMITTER: Siebert A 

PROVIDER: S-EPMC9481933 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature