Protective effects and mechanisms of psoralidin against adriamycin-induced cardiotoxicity.

ABSTRACT:

Introduction

Adriamycin (ADR) is an efficient and common broad-spectrum anticancer drug. However, the cumulative and dose-dependent toxicity induced by ADR severely limits its application in the clinic. Previous studies found that psoralidin (PSO) exhibits remarkable therapeutic effects against multiple cancers.

Objectives

The aim of this study was to determine if PSO has beneficial effects on ADR-induced cardiotoxicity and to investigate the underlying mechanisms.

Methods

ADR-induced cardiotoxicity models were established in BALB/c mice and HL-1 cardiomyocytes. A series of experimental methods were used to evaluate the effects of PSO on cardiac function indicators, blood biochemical parameters, histopathology, oxidative stress, apoptosis, mitochondrial function, fibr

SUBMITTER: Liang Z 

PROVIDER: S-EPMC9481943 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature