Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma.

ABSTRACT:

Introduction

Janus kinase 3 (JAK3) is a well-established oncogene in clear cell renal cell carcinoma (ccRCC). The methylation status of oncogene promoters has emerged as biomarkers for cancer diagnosis and prognosis.

Objective

This study aims to investigate the biological and clinical significance of JAK3 promoter methylation in ccRCC.

Methods

We analyzed the relationship of JAK3 promoter methylation with its mRNA expression, overall survival, and immune cell infiltration in a cohort obtained from The Cancer Genome Atlas (TCGA), which was further validated by another independent cohort. We further validated correlations of JAK3 promoter methylation with JAK3 expression, overall survival, and immune cell infiltration in an independent ccRCC cohort (Sun Yat-sen Universi

SUBMITTER: Long Q 

PROVIDER: S-EPMC9481962 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature