Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis.

ABSTRACT:

Introduction

Ulcerative colitis (UC) is a chronic recurrent idiopathic disease characterized by damage to the colonic epithelial barrier and disruption of inflammatory homeostasis. At present, there is no curative therapy for UC, and the development of effective and low-cost therapies is strongly advocated.

Objectives

Multiple lines of evidence support that tannic acid (TA) and berberine (BBR), two active ingredients derived from Chinese herb pair (Rhei Radix et Rhizoma and Coptidis Rhizoma), have promising therapeutic effects on colonic inflammation. This study aims to develop a targeted delivery system based on BBR/TA-based self-assemblies for the treatment of UC.

Methods

TA and BBR self-assemblies were optimized, and hyaluronic acid (HA) was coated to achieve targe

SUBMITTER: Chen S 

PROVIDER: S-EPMC9481968 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature